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GHK-Cu modulates broad genetic programs, suppresses NF-B , supports DNA repair and proteasomal functions , reducing ROS and cytokines

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Experimental reports have described measurable growth hormone axis signaling after exposure to this receptor pathway research peptide

This effect is mediated by inducing G0/G1 cell cycle arrest in SMMC-7721 hepatocellular carcinoma cells, upregulating the expression of p53 and Bax, and downregulating the expression of Bcl-2 in response to hypoxic conditions, thereby exerting a potent anticancer effect (Zeng et al., 2025)